In the first three games of the season, Arizona Cardinals quarterback Kyler Murray had five runs each week for 57, 59 and 45 yards. That production disappeared in last week’s game against the Washington Commanders when he had only one attempt

It was just the third play Sunday and Kyler Murray was already doing what he does best. With a free rusher off the right side, he sprinted to his left, beat a defender to the corner and turned a busted play into positive yardage. A play later, the Cardinals had a first down. Five plays later, they were in the end zone.

In his best game of the season -- Week 2 versus the Los Angeles Rams -- Kyler Murray finished with 28.5 fantasy points. His stat line: 17-of-21 (81%), 266 yards, 3 TDs, 0 INTs; 5 carries, 59 yards.

A matchup with the offensively challenged New England Patriots was just what the San Francisco 49ers' defense needed to get back on track.

For the most part, the 49ers have defended Kyler Murray well since he got drafted. They've faced him six times and lost only twice. And they've held him to a quarterback rating of 86.5, which is pedestrian.

Check out these betting insights and trends before placing player prop wagers on Kyler Murray for Sunday’s game, which starts at 4:05 PM ET on FOX. Murray and the Arizona Cardinals (1-3) are

Cardinals quarterback Kyler Murray (1) walks to the sidelines after a three and out against the Commanders during a game at State Farm Stadium in Glendale, Ariz., on Sunday, Sept. 29, 2024. / Patrick Breen/The Republic / USA TODAY NETWORK via Imagn Images

When the San Francisco 49ers (2-2) and Arizona Cardinals (1-3) play on Oct. 6 at Levi's Stadium, Brock Purdy and Kyler Murray will be under center for their respective offenses. Which QB has the advantage in this bout? Find out below.

Time/site: 1:05 p.m. MST, Levi’s Stadium, Santa Clara, California. TV: FOX. Radio: 98.7 FM. Last time they played: The 49ers